Author Affiliations
Abstract
Key Laboratory of Optoelectronic Science and Technology for Medicine Ministry of Education, Fujian Provincial Key Lab of Photonic Technology, College of Photonic and Electronic Engineering, Fujian Normal University, Fuzhou 350007, Fujian, P. R. China
Photoacoustic imaging, which can provide the maximum intensity contrast in tissue depth imaging without ionizing radiation, will be a promising imaging trend for tumor detection. In this paper, a column diffusion fiber was employed to carry a pulsed laser for irradiating stomach directly through esophagus based on the characteristics of gastric tissue structure. A long focused ultrasonic transducer was placed outside the body to detect photoacoustic signals of gastric tissue. Phantom and in vitro experiments of submucosal gastric tumors were carried out to check the sensitivity of scanning photoacoustic tomography system, including the lateral and longitudinal resolution of the system, sensitivity of different absorption coe±cient in imaging, capability of transversal detection, and probability of longitudinal detection. The results demonstrate that our innovative technique can improve the parameters of imaging. The lateral resolution reaches 2.09 mm. Then a depth of 5.5mm with a longitudinal accuracy of 0.36mm below gastric mucosa of early gastric cancer (EGC) has been achieved. In addition, the optimal absorption coe±cient differences among absorbers of system are 3.3–3.9 times. Results indicate that our photoacoustic imaging (PAI) system, is based on a long focusing transducer, can provide a potential application for detecting submucosal EGC without obvious symptoms.
Column diffusion fiber long focusing transducer gastric tumor detection scanning photoacoustic tomography phantom experiment 
Journal of Innovative Optical Health Sciences
2019, 12(3): 1950011
作者单位
摘要
福建师范大学医学光电科学与技术教育部重点实验室, 福建省光子技术重点实验室, 福建师范大学物理与光电信息科技学院, 福建 福州 350007
使用OCT技术观察活体小鼠皮肤组织在非消融性激光作用后光热损伤及其修复过程,得出皮肤组织在此过程中形态上的变化规律。利用OCT散射模型得出皮肤在激光作用前后光学参数中衰减系数的变化, 根据所获得的光学参数的变化量来判断热损伤程度, 并分析引起散射参数变化的原因,作为临床上无损的判断光热作用下皮肤内部损伤情况的依据。结果表明OCT是一种很有潜力的活体监测光热损伤及其修复过程的工具。
OCT散射模型 非消融性 光热损伤 OCT scattering mode non-invasive laser optical-thermal damage 
激光生物学报
2010, 19(2): 148

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